Garoppolo participated in the 49ers' team from loyaty's blog

On October 30, 2017, the Patriots traded Garoppolo to the San Francisco 49ers in exchange for the second-round pick of the 49ers in the 2018 NFL Draft. In the first game, in the last minute of the 49ers' match against the Seattle Seahawks, he started 49 people and the starting CJ Beathard was injured; this was his first spiking in 2017 because he didn’t have a goal in 2017. Participate in the Patriots' competition. In his first match as a 49er, he rushed for 6 yards. In the final game of the game, he threw 10 yards touchdown to Louis Murphy NFL Coins. He completed the 24-13 loss, completed two passes of 18 yards and touchdowns.

On November 28, 2017, Garoppolo was named the 13th game of the 49ers against the Chicago Bears. Garoppolo participated in the 49ers' team for the first time on December 3, 2017. At the end of the game, the pass reached 293 times. The 49ers beat the Chicago Bears 15-14. He recorded a 334-yard pass, a touchdown and an interception when he defeated the Houston Texans 26-16 in the 14th week. In the next match against the Tennessee Titans, he had a 381-yard pass yard and was near a 25-23 touchdown. In the 16th week on the eve of Christmas, against the Jacksonville Jaguars, he had a 242-yard pass, two touchdowns, an interception, and his first career career touchdown with a 44-33 victory.